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114
Antiviral Agents
Authors:Last Updated:2023
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Introduction
The number of antiviral agents continues to expand. Most of the agents currently approved by the U.S. Food and Drug Administration (FDA) are active against one or more of the…
1Agents Against HIV‐1 and HIV‐2
There are now five classes of antiviral agents for the treatment of HIV‐1: (i) nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs), (ii) nonucleoside reverse transcriptase inhibitors (NNRTIs), (iii) protease inhibitors (PIs), (iv)…
1Agents Against Hepatitis C Virus
Increased understanding of the genome and virology of HCV has led to advances in the efficacy and tolerability of HCV treatment. Multiple direct‐acting antivirals (DAAs) which interfere with specific steps…
12Agents Against Hepatitis B Virus
Because a large percentage of patients are coinfected with HIV, agents with activity against hepatitis B virus (HBV) are categorized according to whether they have activity against both viruses or…
15Agents Against Herpesviruses
Most of the antiviral compounds that are approved to treat the eight human herpesviruses are nucleoside or nucleotide analogues, which inhibit DNA replication. Several of these compounds require phosphorylation by…
17Agents Against Influenza Viruses
There are three classes of antivirals for the treatment of influenza: neuraminidase inhibitors, cap‐dependent endonuclease inhibitors, and M2 protein inhibitors. The first two classes treat influenza A and B, while…
21Agents Against Sars‐CoV‐2 Virus
Since the first SARS‐CoV‐2 cases were reported in China in December 2019, its treatment has evolved as the virus has constantly changed through random mutations. The current drugs prevent SARS‐CoV‐2…
22Anti‐Sars‐CoV‐2 Monoclonal Antibodies
The anti‐SARS‐CoV‐2 monoclonal antibodies (MAbs) target the virus spike proteins and block their entry into host cells. Several MAbs became available, but their antiviral activity decreased due to changes in…
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Section Editor: Ben Pinsky
Volume Editor: Marie Louise Landry
Editors in Chief: Karen C. Carroll and Michael A. Pfaller
Citation Information
Copyright © 2023 by ASM Press. ASM Press is a registered trademark of the American Society for Microbiology. All rights reserved. No part of this publication may be reproduced or transmitted in whole or in part or reutilized in any form or by any means, electronic or mechanical, including photocopying and recording, or by any information storage and retrieval system, without permission in writing from the publisher.