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Susceptibility Test Methods: Yeasts and Filamentous Fungi
Authors:Last Updated:2023
Antifungal Susceptibility Testing
The groups of antifungal agents licensed for the systemic treatment of invasive fungal infection currently include the polyene amphotericin B and its three lipid formulations; the azoles fluconazole, isavuconazole, itraconazole,…
1Standardized Broth Dilution Methods for Yeasts
Currently, there are two internationally recognized broth dilution methods for testing yeasts such as Candida spp. Broth microdilution testing (Table 3) has become the most widely used reference…
7Yeast Genera Other Than Candida
Although the CLSI and EUCAST methods only provide suggested breakpoints for the most common human‐pathogenic Candida spp. (see Table 1), with certain caveats these methods are broadly suitable…
11Special Considerations
Amphotericin B MICs determined by the microdilution methods are clustered between 0.25 and 1.0 mg/liter for 94% of clinical yeast isolates; ≤1.0 mg/liter is often used as a tentative breakpoint…
12CLSI and EUCAST Clinical Breakpoints and Epidemiological Cutoff Values for Candida spp.
There is now a considerable body of data indicating that standardized antifungal susceptibility testing (38, 40) for Candida spp. and some triazoles, amphotericin B, and the…
13Alternative Approaches for Yeasts
Although the CLSI and EUCAST methods for in vitro susceptibility testing were essential for standardization and for improving interlaboratory reproducibility, they may not be feasible methods for testing all organisms…
14Standardized Broth Dilution Methods for Molds
Antifungal susceptibility testing of molds is becoming increasingly important due to the range of emerging opportunistic pathogens and the reporting of both innate and emergent resistance among the most common…
17Summary and Conclusions
A great deal of progress has been achieved in the field of antifungal susceptibility testing with both yeast and filamentous fungi since testing began in earnest in the early 1980s.…
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Section Editor: Sean Zhang
Volume Editor: Bobbi S. Pritt
Editors in Chief: Karen C. Carroll and Michael A. Pfaller
Citation Information
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